Re-irradiation in conjunction with liposomal doxorubicin for the treatment of skin metastases of recurrent breast cancer: a radiobiological approach and 2 year of follow-up
| Autor: | Lambros Vlahos, John Kouvaris, C. Dardoufas, George A. Plataniotis, Willy Landuyt, Vassilis Kouloulias, Kiki Pistevou-Gompaki, Costas Gennatas |
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| Rok vydání: | 2003 |
| Předmět: |
Re-Irradiation
Cancer Research medicine.medical_specialty Skin Neoplasms Time Factors Liposomal Doxorubicin medicine.medical_treatment Urology Antineoplastic Agents Breast Neoplasms Linear quadratic Group A Group B Risk Factors medicine Humans Neoplasm Metastasis Recurrent breast cancer Radical mastectomy Skin business.industry Middle Aged Surgery Radiation therapy Oncology Doxorubicin Multivariate Analysis Female business Follow-Up Studies |
| Zdroj: | Cancer letters. 193(1) |
| ISSN: | 0304-3835 |
| Popis: | Thirty patients with local relapses after radical mastectomy and radiotherapy and undergoing infusion of liposomal doxorubicin (40 mg/m2 monthly for 6 months) were randomized to receive re-irradiation. Radiotherapy was with either 17 fractions of 1.8 Gy, 5 days a week (N=15, group A) or 4 Gy plus two fractions of 3 Gy the 1st week and six fractions of 3 Gy given every second day (N=15, group B). Eight patients from group A (53.3%) and nine patients (60%) from group B demonstrating a clinically complete response (P=0.9). Grade I/II acute skin toxicity was monitored in 26.6% of patients in group A versus 73.3% in group B. The radiation schedule of group A seems superior for grade I/II acute (P=0.027) and late (P=0.015) skin toxicity. The linear quadratic model enabled the prediction of tumor response as well as normal skin reactions. |
| Databáze: | OpenAIRE |
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