Comparative osteoconductivity of bone void fillers with antibiotics in a critical size bone defect model

Autor: William R. Walsh, Vedran Lovric, Chris Christou, Rema A. Oliver
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Mature Bone
Materials science
Bone Regeneration
Biomedical Engineering
Biophysics
Bioengineering
Biocompatible Materials
Haematoxylin
Calcium Sulfate
Bone and Bones
Biomaterials
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
In vivo
Materials Testing
medicine
Medical technology
Animals
Regeneration
Femur
Bone Resorption
R855-855.5
Author Correction
Materials of engineering and construction. Mechanics of materials
030222 orthopedics
0303 health sciences
Sheep
Dose-Response Relationship
Drug
Tibia
030306 microbiology
X-Ray Microtomography
Resorption
Anti-Bacterial Agents
Drug Combinations
medicine.anatomical_structure
Durapatite
chemistry
Bone Substitutes
TA401-492
Gentamicin
Implant
Bone marrow
Gentamicins
Biocompatibility Studies
Cancellous bone
medicine.drug
Biomedical engineering
Zdroj: Journal of Materials Science: Materials in Medicine, Vol 31, Iss 9, Pp 1-11 (2020)
Journal of Materials Science. Materials in Medicine
ISSN: 1573-4838
0957-4530
Popis: The study aimed to evaluate the comparative osteoconductivity of three commercially available bone void fillers containing gentamicin with respect to new bone, growth, host tissue response and resorption of the implant material. Defects were created in the cancellous bone of the distal femur and proximal tibia of 12-skeletally mature sheep and filled with three commercially available bone void fillers containing gentamicin (Stimulan-G, Cerament-G, Herafill-G). Peripheral blood was taken pre-operatively and at the time of implantation, as well as at intermittent timepoints following surgery to determine systemic gentamicin levels (5-,15- and 30- minutes, 1, 2, 3, 6, 12, 24, 48- and 72-hours, 3-, 6- and 12-weeks). Decalcified, embedded samples were stained with haematoxylin and eosin (H&E) and used to assess the host tissue response and the formation of new bone in the presence of test implant materials. No adverse reactions were noted at harvest at any time points for any cancellous implantation sites with the various implant materials. Comparative microCT analysis of the Stimulan-G, Cerament-G and Herafill-G test materials revealed a similar increase in bone surface area and volume between animals implanted with Stimulan-G or Cerament-G test materials. Animals implanted with Herafill-G test materials demonstrated the lowest increases in bone volume and surface area of the test materials tested, at levels similar to the negative control sites. By 12-weeks, Stimulan-G defects were completely closed with mature bone and bone marrow whilst the Cerament-G material was still present after 12 weeks by histological examination. In conclusion, this study demonstrated differences in the bone regenerative capacity of a range of bone void fillers in an in vivo setting.
Databáze: OpenAIRE
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