Improved stenosis outcome in stroke‐free sickle cell anemia children after transplantation compared to chronic transfusion
| Autor: | David Grevent, Florence Missud, Suzanne Verlhac, Annie Kamdem, Lydia Divialle-Doumdo, Charlotte Jubert, Corinne Guitton, Corinne Pondarré, Isabelle Thuret, Flaviu Gabor, Alexandra Gauthier, Cécile Arnaud, Jean-François Chateil, Philippe Petit, Françoise Bernaudin, Mariane de Montalembert, Marie Petras, Valentine Brousse, Catherine Paillard, Monique Elmaleh |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Adolescent Ultrasonography Doppler Transcranial Blood Donors Anemia Sickle Cell Constriction Pathologic Magnetic resonance angiography 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine Outcome Assessment Health Care medicine Humans Blood Transfusion Prospective Studies Sibling Child Stroke medicine.diagnostic_test business.industry Siblings Hematopoietic Stem Cell Transplantation Brain Hematology medicine.disease Magnetic Resonance Imaging Sickle cell anemia Transcranial Doppler Transplantation Stenosis surgical procedures operative Child Preschool 030220 oncology & carcinogenesis Cardiology Stem cell business human activities Magnetic Resonance Angiography Follow-Up Studies 030215 immunology |
| Zdroj: | British Journal of Haematology. 193:188-193 |
| ISSN: | 1365-2141 0007-1048 |
| Popis: | We report here the 3-year stenosis outcome in 60 stroke-free children with sickle cell anaemia (SCA) and an abnormal transcranial Doppler history, enrolled in the DREPAGREFFE trial, which compared stem cell transplantation (SCT) with standard-care (chronic transfusion for 1-year minimum). Twenty-eight patients with matched sibling donors were transplanted, while 32 remained on standard-care. Stenosis scores were calculated after performing cerebral/cervical 3D time-of-flight magnetic resonance angiography. Fourteen patients had stenosis at enrollment, but only five SCT versus 10 standard-care patients still had stenosis at 3 years. Stenosis scores remained stable on standard-care, but significantly improved after SCT (P = 0·006). No patient developed stenosis after SCT, while two on standard-care did, indicating better stenosis prevention and improved outcome after SCT. |
| Databáze: | OpenAIRE |
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