Expression of Vascular Endothelial Growth Factor in Human Periodontal Tissues: Comparison of Healthy and Diabetic Patients
| Autor: | Mine Hekimgil, Pelin Güneri, Füsun Ünlü, Hayal Boyacioglu, Banu Yeşilbek |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Periodontium Vascular Endothelial Growth Factor A Pathology medicine.medical_specialty Angiogenesis Vascular permeability Endothelial Growth Factors Monocytes Immunoenzyme Techniques Neovascularization chemistry.chemical_compound Diabetes mellitus medicine Humans Periodontitis Lymphokines Neovascularization Pathologic Vascular Endothelial Growth Factors business.industry Macrophages Middle Aged medicine.disease Vascular endothelial growth factor Vascular endothelial growth factor A Diabetes Mellitus Type 2 chemistry Case-Control Studies Intercellular Signaling Peptides and Proteins Periodontics Female medicine.symptom business |
| Zdroj: | Journal of Periodontology. 74:181-187 |
| ISSN: | 1943-3670 0022-3492 |
| DOI: | 10.1902/jop.2003.74.2.181 |
| Popis: | Background: Vascular endothelial growth factor (VEGF) induces proliferation of endothelial cells, stimulates angiogenesis, and increases vascular permeability, but information about its role in periodontal lesions is limited. The aim of this study is to determine the association between VEGF expression in healthy and periodontally diseased tissues of healthy and diabetic patients. Methods: Ten systemically healthy and 10 Type 2 diabetic patients (DM) all diagnosed with periodontitis were enrolled into the study. Gingival samples were collected from both periodontal and healthy sites in all patients. Each patient served as his/her own control. Additionally, 10 people without any systemic or periodontal diseases were enrolled as a negative control group. Results: In the negative control group tissue samples, no VEGF expression was observed. Among the 10 systemically healthy people, no evidence of VEGF was observed in healthy gingival samples, but was found in diseased tissues in 2 cases. In the diabetic patients, VEGF was observed in 4 healthy gingival tissues and in 6 periodontal sites. VEGF was intensely present in monocytes and macrophages. Conclusion: The results of this study show that VEGF is increased in gingival tissues of diabetic patients, especially those with periodontal disease. J Periodontol 2003;74:181-187. |
| Databáze: | OpenAIRE |
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