Comparison of efficacy and complication rates after percutaneous coronary interventions in patients with and without renal insufficiency treated with abciximab
| Autor: | Jörg Rustige, Karlheinz Seidl, Ralf Zahn, Birgit Frilling, Klaus Dönges, Boris Fraiture, Torsten Becker, Jochen Senges, Karl Ernst Siegler, Bernd Mark |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Abciximab Myocardial Infarction Renal function Coronary Disease Platelet Glycoprotein GPIIb-IIIa Complex Immunoglobulin Fab Fragments Internal medicine Medicine Humans Angina Unstable Renal Insufficiency Angioplasty Balloon Coronary Aged business.industry Coronary Stenosis Antibodies Monoclonal Odds ratio Middle Aged medicine.disease Confidence interval Regimen Conventional PCI Cardiology Female Cardiology and Cardiovascular Medicine business Complication Kidney disease medicine.drug |
| Zdroj: | The American journal of cardiology. 89(4) |
| ISSN: | 0002-9149 |
| Popis: | Risk factors for bleeding were found in varying rates in both groups of patients. Neither adjunctive heparin therapy nor risk factors for bleeding complications could sufficiently explain the significantly higher rates of peri-interventional bleeding among patients with impaired renal function. Multivariate analysis of the registry data showed an independent association of renal insufficiency with bleeding complications under abciximab (odds ratio 5.1; 95% confidence interval 1.9 to 13.8). Success rates after PCI under abciximab were comparable in patients with normal and impaired renal function. These data suggest that the effects of abciximab are not entirely independent of renal function. Further investigation of this subject is necessary to find the optimal regimen for patients with impaired renal funtion receiving this highly effective drug. |
| Databáze: | OpenAIRE |
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