Solvent-Free, Continuous Synthesis of Hydrazone-Based Active Pharmaceutical Ingredients by Twin-Screw Extrusion
| Autor: | Evelina Colacino, Francesco Delogu, Deborah E. Crawford, Andrea Porcheddu, Stuart L. James, Aaron S. McCalmont |
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| Přispěvatelé: | Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Green chemistry
General Chemical Engineering Hydantoin Hydrazone 02 engineering and technology 010402 general chemistry 01 natural sciences chemistry.chemical_compound General chemistry Mechanochemistry Environmental Chemistry Organic chemistry [CHIM]Chemical Sciences SDG 7 - Affordable and Clean Energy ComputingMilieux_MISCELLANEOUS Active ingredient chemistry.chemical_classification Renewable Energy Sustainability and the Environment Chemistry General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Solvent Extrusion 0210 nano-technology |
| Zdroj: | ACS Sustainable Chemistry & Engineering ACS Sustainable Chemistry & Engineering, American Chemical Society, 2020, 8 (32), pp.12230-12238. ⟨10.1021/acssuschemeng.0c03816⟩ Crawford, D E, Porcheddu, A, McCalmont, A S, Delogu, F, James, S L & Colacino, E 2020, ' Solvent-Free, Continuous Synthesis of Hydrazone-Based Active Pharmaceutical Ingredients by Twin-Screw Extrusion ', ACS Sustainable Chemistry & Engineering, vol. 8, no. 32, pp. 12230-12238 . https://doi.org/10.1021/acssuschemeng.0c03816 |
| ISSN: | 2168-0485 |
| DOI: | 10.1021/acssuschemeng.0c03816⟩ |
| Popis: | Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup was not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for pharmaceutical products. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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