Pharmacokinetics and pharmacodynamics of serum platinum of gynecologic cancer patients treated with nedaplatin
| Autor: | Osamu Ishiko, Toshiyuki Sumi, Yoshinari Matsumoto, Yooji Hyun, Yoshiya Ando, Sachio Ogita, Eri Nakagawa |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty endocrine system diseases Organoplatinum Compounds Genital Neoplasms Female medicine.medical_treatment Urology chemistry.chemical_element Antineoplastic Agents chemistry.chemical_compound Pharmacokinetics Internal medicine Ascites medicine Carcinoma Humans Nedaplatin Aged Platinum Cisplatin Chemotherapy business.industry Area under the curve General Medicine Middle Aged medicine.disease female genital diseases and pregnancy complications Endocrinology Oncology chemistry Area Under Curve Female medicine.symptom business medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1021-335X |
| Popis: | Nedaplatin (cis-diammine glycolate platinum) is one of the effective platinum agents for gynecologic carcinoma. In order to assess the pharmacokinetics and pharmacodynamics of serum platinum of gynecologic cancer patients treated with nedaplatin, we calculated 10 course AUCs (area under the curve) of the free and total platinum from blood samples of 4 patients. Peak serum platinum concentrations were dependent on infusion times. In the case of a patient with renal dysfunction or ascites, the concentration of serum platinum tended to stay at a high level for a long time. Serum-free platinum ratios were maintained longer than cisplatin. Low dose nedaplatin administration and divided administration were effective, but total AUC was not so great. The relation between AUC ratio (free platinum AUC/total platinum AUC) and dose/m(2) was not clarified. |
| Databáze: | OpenAIRE |
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