Adeno-associated viral vectors as gene delivery vehicles
| Autor: | P J Carter, R J Samulski |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
viruses
Genetic enhancement Genetic Vectors Gene Transfer Techniques General Medicine Human parvovirus Computational biology Dependovirus Biology Gene delivery medicine.disease Virus Virus Latency Viral vector Vector integration Virus latency DNA Transposable Elements Genetics Cancer research medicine Animals Humans Vector (molecular biology) |
| Zdroj: | International Journal of Molecular Medicine. |
| ISSN: | 1791-244X 1107-3756 |
| DOI: | 10.3892/ijmm.6.1.17 |
| Popis: | Adeno-associated virus (AAV), a non-pathogenic human parvovirus, is gaining attention for its potential use as a human gene therapy vector. One of the most attractive features of recombinant AAV vectors is the ability to be stably maintained in host cells as integrated proviruses. This property is particularly desireable for therapies requiring long-term correction of a genetic defect. This review highlights recent advances made in the AAV field and will discuss some limitations of rAAV vector integration. A novel method for enhancing the integration efficiency of these vectors will be presented. |
| Databáze: | OpenAIRE |
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