Urolithiasis with topiramate in nonambulatory children and young adults
| Autor: | Richard I. Grossberg, Ira D. Davis, Monisha Goyal, Mary Ann O'Riordan |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Topiramate
Adult Male medicine.medical_specialty Pediatrics Adolescent Developmental Disabilities Fructose Young Adult Pharmacotherapy Developmental Neuroscience Urolithiasis Intellectual Disability Epidemiology medicine Humans Citrates Young adult Adverse effect Child Retrospective Studies business.industry Middle Aged medicine.disease Surgery Clinical trial Neurology El Niño Child Preschool Pediatrics Perinatology and Child Health Kidney stones Anticonvulsants Female Neurology (clinical) business medicine.drug |
| Zdroj: | Pediatric neurology. 40(4) |
| ISSN: | 0887-8994 |
| Popis: | Urolithiasis occurs infrequently in the pediatric population, where metabolic factors play a primary role in the pathogenesis of stone formation. Topiramate, an antiepileptic drug, is associated with a kidney stone in 1.5% of patients in published clinical trials. However, this risk may be much higher in certain populations with multiple preexisting risk factors. We performed a retrospective review of all nonambulatory and neurologically impaired individuals in a long-term care facility. Three groups were involved: those with no exposure to antiepileptic drugs, those on antiepileptic drugs other than topiramate, and those who had been treated with topiramate. Thirteen of 24 (54%) individuals on topiramate monotherapy or polytherapy developed clinical evidence of urolithiasis after a mean duration of 36.4 months. Our results suggest that nonambulatory and neurologically impaired individuals in a long-term care facility appear to be at higher risk of developing kidney stones with topiramate than previously reported. |
| Databáze: | OpenAIRE |
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