Differential effects of lorazepam and oxazepam on priming
| Autor: | Curran Hv, Gorenstein C |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Audiology Lorazepam behavioral disciplines and activities Double-Blind Method Memory mental disorders medicine Explicit memory Humans Pharmacology (medical) Memory disorder Episodic memory Analysis of Variance Psychological Tests Oxazepam medicine.disease Psychiatry and Mental health Free recall Anesthesia Finger tapping Mental Recall Female Implicit memory Psychology psychological phenomena and processes medicine.drug |
| Zdroj: | International clinical psychopharmacology. 8(1) |
| ISSN: | 0268-1315 |
| Popis: | The effects of lorazepam (2 mg), oxazepam (30 mg) and placebo on performance in implicit and explicit memory tasks were compared in a double-blind, independent group study with 36 healthy volunteers. Both benzodiazepines (BZs) impaired performance on the explicit task (free recall). However, only lorazepam impaired performance of the implicit task (word-stem completion). A similar pattern of drug effects was observed on a secondary task which used different instructions at stimulus presentation. BZ effects on the explicit task were more associated with levels of sedation (indexed by finger tapping speed) than their effects on the implicit task. It is concluded that both BZs impair episodic memory but only lorazepam impairs priming. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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