Using high sensitivity cardiac troponin values in patients with SARS-CoV-2 infection (COVID-19): The Padova experience

Autor: Allan S. Jaffe, Yader Sandoval, Luciano Babuin, Stefania Vigolo, Sabino Iliceto, Francesco Favretto, Laura De Michieli, Sandra C. Bryant, Ronstan Lobo, Daniele Donato, Vito Cianci, Roberto Vettor, Alessandro Lunardon, Giulia Berti de Marinis, Mario Plebani
Rok vydání: 2021
Předmět:
Male
030213 general clinical medicine
medicine.medical_specialty
Cardiac troponin
Coronavirus disease 2019 (COVID-19)
High-sensitivity cardiac troponin I
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Clinical Biochemistry
Myocardial Infarction
Outcomes
030204 cardiovascular system & hematology
Risk Assessment
Article
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Internal medicine
medicine
Humans
In patient
Risk stratification
Aged
Retrospective Studies
Aged
80 and over
SARS-CoV-2
business.industry
Troponin I
COVID-19
Retrospective cohort study
General Medicine
Emergency department
Middle Aged
Prognosis
Confidence interval
Hospitalization
Italy
Myocardial injury
Female
Cardiomyopathies
Emergency Service
Hospital
business
Biomarkers
Zdroj: Clinical Biochemistry
ISSN: 0009-9120
Popis: Background The spectrum of Coronavirus Disease 2019 (COVID-19) is broad and thus early appropriate risk stratification can be helpful. Our objectives were to define the frequency of myocardial injury using high-sensitivity cardiac troponin I (hs-cTnI) and to understand how to use its prognostic abilities. Methods Retrospective study of patients with COVID-19 presenting to an Emergency Department (ED) in Italy in 2020. Hs-cTnI was sampled based on clinical judgment. Myocardial injury was defined as values above the sex-specific 99th percentile upper reference limits (URLs). Most data is from the initial hospital value. Results 426 unique patients were included. Hs-cTnI was measured in 313 (73.5%) patients; 85 (27.2%) had myocardial injury at baseline. Patients with myocardial injury had higher mortality during hospitalization (hazard ratio = 9 [95% confidence interval (CI) 4.55–17.79], p 13 [OR (95% CI): 0.48 (0.08, 2.65), p = 0.40]. Initial hs-cTnI
Databáze: OpenAIRE
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