Antidiarrhoeal investigation of Apium leptophyllum (Pers.) by modulation of Na+K+ATPase, nitrous oxide and intestinal transit in rats
| Autor: | Subrat Kumar Bhattamishra, Anjan Kumar, Himanshu Bhusan Sahoo, Rakesh Sagar, Amrita Bhaiji |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Loperamide medicine.drug_class medicine.medical_treatment Prostaglandin Enteropooling Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Antidiarrhoeal Medicine Na+/K+-ATPase lcsh:QH301-705.5 Apium leptophyllum Apium Castor oil lcsh:R5-920 biology Traditional medicine business.industry General Medicine biology.organism_classification Na+K+ATPase Small intestine 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) chemistry Biochemistry 030220 oncology & carcinogenesis Intestinal transit lcsh:Medicine (General) business medicine.drug Prostaglandin E |
| Zdroj: | Biomedical Journal, Vol 39, Iss 6, Pp 376-381 (2016) |
| ISSN: | 2319-4170 |
| DOI: | 10.1016/j.bj.2016.11.003 |
| Popis: | Background: Apium leptophyllum (Pers.) is an annual herb with traditional appreciation for various pharmacological properties; however, the scientific information on this herb is insufficient. The aim of the present investigation was undertaken to evaluate flavonoidal fraction of A. leptophyllum fruit (FFALF) against diarrhoea on albino rats. Methods: The antidiarrhoeal study was conducted by castor oil induce diarrhoea, prostaglandin E2 (PGE2) induced enteropooling and intestinal transit by charcoal meal test. The rats were divided into five groups (six/group). Group I served as control and received orally 2% acacia suspension; Group II served as standard and received orally loperamide (3 mg/kg) or atropine sulphate (5 mg/kg); Group III, IV and V served as test groups and received the FFALF at doses of 5, 10 and 20 mg/kg orally, respectively. Results: In castor oil-induced diarrhoeal model, the FFALF significantly (p |
| Databáze: | OpenAIRE |
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