A case-control genome wide association study of substance use disorder (SUD) identifies novel variants on chromosome 7p14.1 in patients from the United Arab Emirates (UAE)
| Autor: | Mansour Shawky, Hiba Alblooshi, Ahmed El Kashef, Guan K. Tay, Hamad Al Ghaferi, Holly Fisher, Gary K. Hulse, Stuart Reece, Habiba Al Safar, Heather J. Cordell |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Genotype Substance-Related Disorders Population United Arab Emirates Locus (genetics) Single-nucleotide polymorphism Genome-wide association study Biology Polymorphism Single Nucleotide Cohort Studies 03 medical and health sciences Cellular and Molecular Neuroscience SNP Humans Genetic Predisposition to Disease education Genetics (clinical) Genetic association Genetics Chromosome 7 (human) education.field_of_study Australia Psychiatry and Mental health 030104 developmental biology Case-Control Studies Cohort Chromosomes Human Pair 7 Genome-Wide Association Study |
| Zdroj: | American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 180(1) |
| ISSN: | 1552-485X |
| Popis: | Genome wide association studies (GWASs) have provided insights into the molecular basis of the disorder in different population. This study presents the first GWAS of substance use disorder (SUD) in patients from the United Arab Emirates (UAE). The aim was to identify genetic association(s) that may provide insights into the molecular basis of the disorder. The GWAS discovery cohort consisted of 512 (250 cases and 262 controls) male participants from the UAE. Controls with no prior history of SUD were available from the Emirates family registry. The replication cohort consisted of 520 (415 cases and 105 controls) Australian male Caucasian participants. The GWAS discovery samples were genotyped for 4.6 million single nucleotide polymorphism (SNP). The replication cohort was genotyped using TaqMan assay. The GWAS association analysis identified three potential SNPs rs118129027 (p-value = 6.24 × 10-8 ), rs74477937 (p-value = 8.56 × 10-8 ) and rs78707086 (p-value = 8.55 × 10-8 ) on ch7p14.1, that did not meet the GWAS significance threshold but were highly suggestive. In the replication cohort, the association of the three top SNPs did not reach statistical significance. In a meta-analysis of the discovery and the replication cohorts, there were no strengthen evidence for association of the three SNPs. The top identified rs118129027 overlaps with a regulatory factor (enhancer) region that targets three neighboring genes LOC105375237, LOC105375240, and YAE1D1. The YAE1D1, which represents a potential locus that is involved in regulating translation initiation pathway. Novel associations that require further confirmation were identified, suggesting a new insight to the genetic basis of SUD. |
| Databáze: | OpenAIRE |
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