Predictors of response to insulin therapy in youth with poorly‐controlled type 2 diabetes in the TODAY trial
| Autor: | Fida, Bacha, Laure, El Ghormli, Silva, Arslanian, Philip, Zeitler, Lori M, Laffel, Lorraine E, Levitt Katz, Rachelle, Gandica, Nancy T, Chang, Jennifer E, Sprague, Sarah A, Macleish, J, Silverstein |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Randomization Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes Biomarkers Pharmacological Article 03 medical and health sciences 0302 clinical medicine Internal medicine Internal Medicine Humans Insulin Medicine Treatment Failure 030212 general & internal medicine Child Glycemic Glycated Hemoglobin Adiponectin business.industry nutritional and metabolic diseases Type 2 Diabetes Mellitus Prognosis medicine.disease Metformin Treatment Outcome Diabetes Mellitus Type 2 Pediatrics Perinatology and Child Health Female Insulin Resistance business Psychosocial medicine.drug |
| Zdroj: | Pediatr Diabetes |
| ISSN: | 1399-5448 1399-543X |
| DOI: | 10.1111/pedi.12906 |
| Popis: | OBJECTIVE: To understand the factors associated with glycemic control after starting insulin in youth with type 2 diabetes following glycemic failure (persistent HbA1c ≥8%) with metformin alone, metformin+rosiglitazone or metformin+lifestyle in the TODAY study. METHODS: Change in HbA1c after add-on insulin therapy and the factors predictive of glycemic response were evaluated. At one-year post-insulin initiation, 253 youth had a mean of 3.9±1.0 visits since the time of insulin initiation. Participants were divided into three groups according to glycemic control: consistent decrease in HbA1c by ≥0.5%, change < 0.5%, or consistent increase in HbA1c ≥0.5%, at 75% or more of the visits. RESULTS: Within one-year post-insulin initiation, 33.2% of participants had a consistent HbA1c decrease of ≥0.5%, 46.2% changed HbA1c |
| Databáze: | OpenAIRE |
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