Fatal disseminated cowpox virus infection in an adolescent renal transplant recipient
| Autor: | Paul Gazzani, Jeff Martin, Hugh Morton, Joanna E. Gach, David V. Milford, Isabel Colmenero, Kevin E. Brown |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Nephrology medicine.medical_specialty Pathology Adolescent Multiple Organ Failure medicine.medical_treatment Cowpox 030106 microbiology Population Tonsillitis Polymerase Chain Reaction Skin Diseases 03 medical and health sciences Fatal Outcome Internal medicine medicine Humans Renal Insufficiency Chronic Cowpox virus education education.field_of_study business.industry Immunosuppression medicine.disease Kidney Transplantation Dermatology Transplant Recipients Anti-Bacterial Agents Transplantation 030104 developmental biology Pediatrics Perinatology and Child Health business Kidney disease |
| Zdroj: | Pediatric Nephrology. 32:533-536 |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/s00467-016-3534-y |
| Popis: | A 17-year-old boy on long-term immunosuppression following renal transplantation for chronic kidney disease (CKD), the result of dysplastic kidneys, initially presented with a swelling in his neck while attending hospital for an unrelated problem. A clinical diagnosis of tonsillitis was made, and he was treated with broad-spectrum antibiotics. Over a few days, his condition deteriorated, and he developed multiple vesicopustular skin lesions and required an emergency tonsillectomy due to respiratory distress. Histological investigation of the skin and tonsillar tissue suggested a viral aetiology, and subsequent electron microscopy and polymerase chain reaction (PCR) tissue examination proved disseminated cowpox infection. The family cat, which was reported as having self-resolving sores on its skin, was likely the source of the infection. The child failed to respond to antiviral treatment and succumbed to multiorgan failure within a month of admission. We report this case of fatal disseminated cowpox infection to highlight an increasing risk of this illness in the post-transplant population and to detail some unusual features not previously described, such as tonsillar involvement, disseminated skin lesions and multiorgan failure. |
| Databáze: | OpenAIRE |
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