Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia
| Autor: | H I Robins, P Gerke, Jürgen Steinhoff, W Filejski, G. J. Wiedemann |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Hyperthermia Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Urology Kidney Carboplatin Nephrotoxicity chemistry.chemical_compound Clinical Trials Phase II as Topic Antineoplastic Combined Chemotherapy Protocols medicine Albuminuria Humans Ifosfamide Antineoplastic Agents Alkylating Etoposide Aged Glycoproteins Chemotherapy Membrane Glycoproteins business.industry Sarcoma Hyperthermia Induced General Medicine Middle Aged medicine.disease Antineoplastic Agents Phytogenic Nitrogen mustard Oncology chemistry Creatinine Immunoglobulin G Anesthesia Neoplastic cell Female Trypsin Inhibitor Kunitz Soybean business Glomerular Filtration Rate medicine.drug |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 126:173-177 |
| ISSN: | 1432-1335 0171-5216 |
| DOI: | 10.1007/s004320050028 |
| Popis: | Although whole-body hyperthermia combined with specific genotoxic chemotherapy can be shown to enhance neoplastic cell killing without a concomitant rise in bone marrow toxicity, nephrotoxicity can become treatment-limiting. This study compares the kidney toxicity to the kidney of ifosfamide, carboplatin and etoposide (ICE) chemotherapy alone, and ICE chemotherapy combined with either extracorporeal (e-WBH) or radiant-heat-induced hyperthermia (r-WBH) in 43 patients with refractory sarcoma. Within 3 days of ICE chemotherapy treatment there was a significant increase in urinary protein excretion and a reduction of the glomerular filtration rate. These effects were more pronounced if WBH was added. The use of immunoluminometric assays revealed a predominance of low-molecular-mass proteins. This increase in protein excretion persisted in the e-WBH-treated group, whereas it vanished within 3 weeks in both the group treated with ICE alone and that treated with r-WBH. Our findings suggest that ICE chemotherapy causes transient tubular and glomerular damage, which is enhanced by WBH. In terms of long-term nephrotoxicity e-WBH was more nephrotoxic than r-WBH. This finding is consistent with our clinical observations. |
| Databáze: | OpenAIRE |
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