Long-chain polyunsaturated fatty acids in infant formula and cardiovascular markers in childhood
| Autor: | Linda P.M. Pluymen, Lenie van Rossem, Geertje W. Dalmeijer, Henriette A. Smit, Cornelis K. van der Ent, Cuno S.P.M. Uiterwaal |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Pediatrics 030204 cardiovascular system & hematology Cardiovascular System Carotid Intima-Media Thickness Cohort Studies 0302 clinical medicine Obstetrics and Gynaecology Medicine 030212 general & internal medicine Prospective Studies Prospective cohort study Netherlands chemistry.chemical_classification Nutrition and Dietetics IMT Obstetrics and Gynecology Perinatology and Child Health DHA Carotid Arteries Child Preschool Cohort Fatty Acids Unsaturated Blood pressure Infant formula Female Public Health Polyunsaturated fatty acid Cohort study medicine.medical_specialty 03 medical and health sciences Journal Article Humans Pediatrics Perinatology and Child Health Fatty acids business.industry Environmental and Occupational Health Public Health Environmental and Occupational Health Original Articles Confidence interval Cardiovascular health chemistry Pediatrics Perinatology and Child Health Dietary Supplements business Breast feeding |
| Zdroj: | Matern Child Nutr Maternal and Child Nutrition, 14(2). Wiley-Blackwell Publishing Ltd |
| ISSN: | 1740-8695 |
| Popis: | To investigate whether children who consumed infant formula supplemented with long‐chain polyunsaturated fatty acids (LCPUFAs) had a more favourable cardiovascular profile than children who consumed formula without these fatty acids, we used the Wheezing Illnesses Study Leidsche Rijn, a birth cohort that included 2,468 newborns between 2001 and 2014. Data on infant feeding were obtained by questionnaires. At age 5, blood pressure, carotid intima‐media thickness (CIMT), and carotid distension were measured. We used multivariable linear regression analysis to compare levels of cardiovascular markers in formula‐fed children born before and after the LCPUFA supplementation. To account for secular trends, we compared levels of cardiovascular markers in a control group of breastfed children from the same cohort born before and after the supplementation. Formula‐fed children born after the LCPUFA supplementation (n = 48) had no different systolic blood pressure (−2.58 mmHg, 95% confidence interval, CI [−5.5, 0.30]), diastolic blood pressure (−0.13 mmHg, 95% CI [−2.3, 2.1]), or carotid distension (24.8 MPa(−1), 95% CI [−47.1, 96.6]) and had a higher CIMT (18.6 μm, 95% CI [3.7, 33.5]) than formula‐fed children born before the supplementation (n = 163). In the control group, children born after the LCPUFA supplementation (n = 98) had no different systolic‐ or diastolic‐blood pressure, or CIMT, and a higher carotid distension than children born before the supplementation (n = 142). In conclusion, children who consumed infant formula supplemented with LCPUFAs did not have a more favourable cardiovascular profile in early childhood than children who consumed formula without LCPUFAs. |
| Databáze: | OpenAIRE |
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