Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways
| Autor: | Cynthia Rodriguez-Jamardo, Carolina Barreiro-Villar, Elena de Las Heras, Carlos Spuch, José Manuel Olivares, Tania Rivera-Baltanás, Alejandro García-Caballero, Patricia Fernández-Palleiro, Daniela Rodrigues-Amorim, María Del Carmen Vallejo-Curto, Marta López, María Álvarez-Ariza, Maria Blanco-Formoso |
|---|---|
| Přispěvatelé: | Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina |
| Rok vydání: | 2019 |
| Předmět: |
Proteomics
Gene isoform lcsh:RC435-571 glia maturation factor beta Glia maturation factor beta Rab3 GTPaseactivating protein catalytic subunit Bioinformatics Brain-derived neurotrophic factor 03 medical and health sciences 0302 clinical medicine proteomics Neurotrophic factors lcsh:Psychiatry mental disorders medicine Original Research Psychiatry business.industry brain-derived neurotrophic factor Liquid chromatography–tandem mass spectrometry Rab3 GTPase-activating protein catalytic subunit medicine.disease 030227 psychiatry schizophrenia Psychiatry and Mental health Schizophrenia Potential biomarkers Etiology liquid chromatography–tandem mass spectrometry Signal transduction business 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Psychiatry Frontiers in Psychiatry, Vol 10 (2019) Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname |
| ISSN: | 1664-0640 |
| Popis: | Schizophrenia is a severe and disabling psychiatric disorder with a complex and multifactorial etiology. The lack of consensus regarding the multifaceted dysfunction of this ailment has increased the need to explore new research lines. This research makes use of proteomics data to discover possible analytes associated with psychoneuroimmune signaling pathways in schizophrenia. Thus, we analyze plasma of 45 patients [10 patients with first-episode schizophrenia (FES) and 35 patients with chronic schizophrenia] and 43 healthy subjects by label-free liquid chromatography–tandem mass spectrometry. The analysis revealed a significant reduction in the levels of glia maturation factor beta (GMF- β), the brain-derived neurotrophic factor (BDNF), and the 115-kDa isoform of the Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) in patients with schizophrenia as compared to healthy volunteers. In conclusion, GMF-β, BDNF, and 115-kDa isoform of RAB3GAP1 showed significantly reduced levels in plasma of patients with schizophrenia, thus making them potential biomarkers in schizophrenia. This work was financially backed by the Foundation for Science and Technology (FCT, Fundação para a Ciência e Tecnologia) within the framework of grant SFRH/BD/135623/2018 awarded to Daniela Rodrigues- Amorim, and another grant of Fundación Tatiana Pérez de Guzmanel Bueno provided to Carlos Spuch. Our research was further supported by the Carlos III Health Institute (ISCIII, Instituto Carlos III) through grant P16/00405 and co-funding awarded by the Spanish Foundation of Rare Diseases (FEDER, Fundación Española de Enfermedades Raras) to José Manuel Olivares SI |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|