Prognostic significance of serum lactate following cardiac transplantation

Autor:	Marta Załęska-Kocięcka, Jonathan Dutton, Marco Morosin, Rita Fernandez Garda, Katarzyna Piotrowska, Nicholas Lees, TC Aw, Diana García Sáez, Andre R Simon, Ulrich Stock, Ana Hurtado Doce
Rok vydání:	2022
Předmět:	Biochemistry (medical) Clinical Biochemistry Drug Discovery Heart Transplantation Humans Hyperlactatemia Lactic Acid Prognosis Retrospective Studies
Zdroj:	Biomarkers in Medicine. 16:599-611
ISSN:	1752-0371 1752-0363
DOI:	10.2217/bmm-2021-1041
Popis:	Aim: Hyperlactatemia is common post-heart transplantation. Lactate measurements in the first 24 h were analyzed with respect to mortality. Methods: A total of 153 consecutive cardiac transplant patients were reviewed. Recipients of organs maintained in a state of ex vivo perfusion were included. Results: A total of 143 heart recipients were included. Hyperlactatemia (>2 mmol/l) was present in all patients. Despite maximum lactate and lactate clearance being significantly higher in nonsurvivors (p = 0.002, p = 0.004), neither receiver operator curve analysis nor multivariate logistic regression showed association with 1-year mortality. In comparison, the minimum lactate was significantly associated with mortality (area under the curve 0.728 [p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb24565d8e29b5a6cc5af09d404c59b https://doi.org/10.2217/bmm-2021-1041 Zobrazit plný text záznamu