Hypothalamic lesions in the weanling rat alter pancreatic response to glucose
| Autor: | R.E. Dobbs, Willis K. Samson, J.H. Moltz, C.P. Fawcett |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Sympathetic Nervous System medicine.medical_treatment Glucose challenge Weanling Weaning Biology Glucagon Bolus (medicine) Internal medicine Insulin Secretion medicine Animals Insulin geography geography.geographical_feature_category General Neuroscience Rats Inbred Strains Syndrome Islet In vitro Rats Glucose Endocrinology Ventromedial Hypothalamic Nucleus Hypothalamus Hypothalamic Diseases |
| Zdroj: | Brain Research Bulletin. 13:673-677 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/0361-9230(84)90200-4 |
| Popis: | Circulating levels of insulin and glucagon were monitored daily in weanling rats bearing bilateral radiofrequency lesions of the hypothalamic region comprising the ventral pole of the dorsomedial nucleus and at least one third of the dorsal pole of the ventromedial nucleus (V-DMH). Plasma insulin levels in the animals with lesions were significantly elevated by the eighth post-lesion day while plasma glucagon levels were significantly reduced by the 13th day. An intravenous glucose bolus administered to conscious unrestrained animals with lesions had no significant effect on circulating insulin levels but resulted in a dramatic increase in circulating glucagon levels. The IV glucose injections had no significant effect on circulating glucagon levels in the sham-lesioned and unoperated controls while the plasma insulin levels in both control groups were significantly elevated. After a glucose challenge in vitro (300 mg%), insulin release by islets from the lesioned animals showed only a slight increase whereas glucagon release was paradoxically increased. These results provide evidence for an abnormal glucose-sensing function of the pancreatic islet after hypothalamic lesions. |
| Databáze: | OpenAIRE |
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