Herpes Labialis: A New Possibility for Topical Treatment with Well-Elucidated Drugs
| Autor: | Dyenefer P. Fonseca, Maíra P. Ferreira, Fabiana T. M. C. Vicentini, Érica Benassi-Zanqueta, Vinícius Pedrazzi, Amanda F. Silva-Alvarez, Tania Ueda-Nakamura, Thalita Zago Oliveira, Ana Clara Wada de Carvalho, Osvaldo de Freitas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Lidocaine
Administration Topical Pharmaceutical Science 02 engineering and technology Absorption (skin) Pharmacology medicine.disease_cause Antiviral Agents 030226 pharmacology & pharmacy Prilocaine Ointments Lesion 03 medical and health sciences 0302 clinical medicine In vivo medicine Humans Anesthetics Local Herpes Labialis business.industry 021001 nanoscience & nanotechnology medicine.disease Cold sore Herpes simplex virus medicine.symptom 0210 nano-technology business medicine.drug |
| Zdroj: | Journal of Pharmaceutical Sciences. 110:3450-3456 |
| ISSN: | 0022-3549 |
| DOI: | 10.1016/j.xphs.2021.06.029 |
| Popis: | Mucocutaneous infections caused by Herpes simplex virus (HSV-1 and HSV-2) are characterized by the appearance of vesicles that cause pain and embarrassment to the carrier. The standard treatment is based on the use of antivirals in gels or ointments, however, relapses are common. Local anesthetics decrease the pain caused by the lesion, in addition to showing antiviral properties. Semi-solid form facilitates application and its transformation into a thin film favors the maintenance of the formulation in place, with a more discreet final aspect. The objective of this study was to develop and evaluate formulations containing anesthetics for the treatment of cold sores. For this purpose, two semi-solid film-forming formulations were developed and evaluated, containing HPMC K100, lidocaine (LIDO) and prilocaine (PRILO) combined with adjuvants, in the presence (F1T) or not (F1) of the absorption promoter Transcutol®. The mixture of PRILO and LIDO resulted in the formation of a eutectic mixture (EM), essential for penetration of drugs into the skin. The quantification of drugs was performed by HPLC (High Performance Liquid Chromatography), and Transcutol® did not influence the release of drugs from the formulation. The bioadhesiveness of the formulation was evaluate and the drugs did not impair the adhesive potential of the polymers used. The formulations were evaluated in vivo for skin irritation and did not show any negative sign on macroscopic examination. The in vivo efficacy test proved the anesthetics' ability to decrease the lesions caused by HSV-1. Thus, the proposed formulations proved to be good alternatives to the treatment of oral lesions caused by HSV-1. |
| Databáze: | OpenAIRE |
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