Gram-Scale Synthesis of the (-)-Sparteine Surrogate and (-)-Sparteine

Autor:	Leigh Ferris, Peter O'Brien, James D. Firth, Steven J. Canipa
Rok vydání:	2017
Předmět:	Natural product 010405 organic chemistry Chemistry Enantioselective synthesis Sparteine Total synthesis General Medicine General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Kinetic resolution chemistry.chemical_compound Yield (chemistry) medicine Organic chemistry medicine.drug Gram
Zdroj:	Angewandte Chemie (International ed. in English). 57(1)
ISSN:	1521-3773 1433-7851
Popis:	An 8-step, gram-scale synthesis of the (-)-sparteine surrogate (22 % yield, with just 3 chromatographic purifications) and a 10-step, gram-scale synthesis of (-)-sparteine (31 % yield) are reported. Both syntheses proceed with complete diastereocontrol and allow access to either antipode. Since the syntheses do not rely on natural product extraction, our work addresses long-term supply issues relating to these widely used chiral ligands.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cadac6858c823c5cfc1faf6cfbf39e8 https://pubmed.ncbi.nlm.nih.gov/29155468 Zobrazit plný text záznamu Plný text