[Acute toxicity studies of taltirelin tetrahydrate in mice, rats, and dogs]

Autor:	Takaaki Yamamura, Hiroshi Kuse, Yoshiaki Kawai, Naoki Hishida, Michishige Noguchi, Masaki Hori
Rok vydání:	1998
Předmět:	Male medicine.medical_specialty Vomiting Sedation Injections Subcutaneous Administration Oral Mice Inbred Strains Hyperkinesis Toxicology Beagle Taltirelin Lethal Dose 50 chemistry.chemical_compound Mice Dogs Internal medicine Tachycardia Tremor medicine Animals Rats Wistar Thyrotropin-Releasing Hormone Nootropic Agents Tetrahydrate Dose-Response Relationship Drug Chemistry Acute toxicity Rats Endocrinology Female dog Injections Intravenous Female medicine.symptom Salivation Hormone
Zdroj:	The Journal of toxicological sciences. 22
ISSN:	0388-1350
Popis:	The acute toxicity studies of taltirelin tetrahydrate (TA-0910), a new thyrotropin-releasing hormone (TRH) analogue, were performed in Slc:ddY mice, Slc:Wistar rats and beagle dogs of both sexes. The drug was administered to mice and rats by oral(p.o.), intravenous (i.v.) and subcutaneous (s.c.) routes, and to dogs by the p.o. and i.v. routes. LD
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cad03ef6fb43659db330d14e7b50a8f https://pubmed.ncbi.nlm.nih.gov/9430092 Zobrazit plný text záznamu