Weak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study
| Autor: | Enric Sánchez, Mohsen Kerkeni, Marta Hernández, Ricard Gavaldà, Ferran Rius, Ariadna Sauret, Gerard Torres, Marcelino Bermúdez-López, Elvira Fernández, Eva Castro-Boqué, Francisco Purroy, Dídac Mauricio, Cristina Farràs-Sallés, Miquel Buti, Pere Godoy, Reinald Pamplona, Albert Lecube |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Glycated Hemoglobin
Male Nutrition and Dietetics Optical Imaging Glycosylated hemoglobin Middle Aged Fluorescence Prediabetic State Skin autofluorescence Cross-Sectional Studies advanced glycation end-products glycosylated hemoglobin prediabetes skin autofluorescence Humans Female Advanced glycation end-products Prediabetes Food Science Skin |
| Zdroj: | Nutrients; Volume 14; Issue 5; Pages: 1102 Nutrients r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Repositorio Abierto de la UdL Universitad de Lleida |
| ISSN: | 2072-6643 |
| Popis: | A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation in subjects with prediabetes, and whether or not this measurement could assist in the diagnosis of prediabetes is unclear. A cross-sectional study was conducted in 4181 middle-aged subjects without diabetes. Prediabetes (n = 1444) was defined as a glycosylated hemoglobin (HbA1c) level between 39 and 47 mmol/mol (5.7 to 6.4%), and skin autofluorescence (SAF) measurement was performed to assess AGEs. A multivariable logistic regression model and receiver operating characteristic curve were used. The cohort consisted of 50.1% women with an age of 57 [52;62] years, a BMI of 28.3 [25.4;31.6] kg/m2, and a prevalence of prediabetes of 34.5%. Participants with prediabetes showed higher SAF than control participants (2.0 [1.7;2.2] vs. 1.9 [1.7;2.2], p < 0.001). However, HbA1c was not significantly correlated with SAF levels (r = 0.026, p = 0.090). In addition, the SAF level was not independently associated with prediabetes (OR = 1.12 (0.96 to 1.30)). Finally, there was no good cutoff point for SAF to identify patients with prediabetes (AUC = 0.52 (0.50 to 0.54), sensitivity = 0.61, and 1-specificity = 0.56). Given all of this evidence, we can conclude that although there is an increase in SAF levels in participants with prediabetes, the applicability and clinical relevance of the results is low in this population. |
| Databáze: | OpenAIRE |
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