Vitamin D-dependent Hypercalcemia
| Autor: | Karl P. Schlingmann |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Vitamin
medicine.medical_specialty Endocrinology Diabetes and Metabolism chemistry.chemical_element Rickets Calcium chemistry.chemical_compound Endocrinology CYP24A1 Internal medicine Vitamin D and neurology Endocrine system Medicine Humans Hypercalciuria Vitamin D Vitamin D3 24-Hydroxylase business.industry medicine.disease Hypervitaminosis D Nephrocalcinosis chemistry Mutation Hypercalcemia business |
| Zdroj: | Endocrinology and metabolism clinics of North America. 50(4) |
| ISSN: | 1558-4410 |
| Popis: | Vitamin D metabolism represents a well-integrated, hormonally regulated endocrine unit interlinking calcium and phosphate metabolism. Pathophysiologic processes disturbing vitamin D metabolism comprise classic defects of vitamin D activation and action presenting as different forms of vitamin D-dependent rickets as well as disorders with increased vitamin D activity. The latter may result in hypercalcemia, hypercalciuria, and renal calcifications. Acquired and hereditary disorders causing hypervitaminosis D are discussed, including vitamin D intoxication, granulomatous disease, and idiopathic infantile hypercalcemia that may be caused by either a defective vitamin D degradation or by a primary defect in phosphate conservation. |
| Databáze: | OpenAIRE |
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