Iron oxide nanoparticles for targeted imaging of liver tumors with ultralow hepatotoxicity
| Autor: | Keying Long, Xiaohui Wang, Juanjuan Li, Ruitao Cha, Xingyu Jiang, Yulong Zhang, Pangye Gao, Hongbo Guo, Fengshan Zhou |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Liver tumor
Biocompatibility medicine.diagnostic_test Biomedical Engineering Nanoparticle Magnetic resonance imaging 02 engineering and technology General Chemistry General Medicine 010402 general chemistry 021001 nanoscience & nanotechnology medicine.disease 01 natural sciences Hemolysis 0104 chemical sciences chemistry.chemical_compound chemistry In vivo Cancer research medicine General Materials Science 0210 nano-technology Cytotoxicity Iron oxide nanoparticles |
| Zdroj: | Journal of Materials Chemistry B. 6:6413-6423 |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/c8tb01657g |
| Popis: | Even though iron oxide (Fe3O4) nanoparticles are promising materials for magnetic resonance imaging (MRI) contrast agents, their biocompatibility and targeting efficacy still need to be improved. Herein, we modified glycyrrhetinic acid (GA) groups on Fe3O4 nanoparticles (Fe3O4@cGlu-GA) for liver tumor-targeted imaging. To evaluate the biocompatibility of these nanoparticles, we studied their cytotoxicity, hemolysis, and hepatotoxicity. We measured the uptake of Fe3O4@cGlu-GA nanoparticles in normal and liver tumor cells, then we investigated the specificity of Fe3O4@cGlu-GA nanoparticles in mouse models bearing subcutaneous and orthotopic liver tumors. With good biocompatibility and targeting efficacy both in vitro and in vivo, the Fe3O4@cGlu-GA nanoparticles are promising MRI contrast agents with ultralow hepatotoxicity and show great improvement on existing Fe3O4-based nanoparticles. |
| Databáze: | OpenAIRE |
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