1,3,5-Triazine as core for the preparation of dendrons
| Autor: | Anamika Sharma, Fernando Albericio, Beatriz G. de la Torre, Rotimi Sheyi, Ayman El-Faham, Ashok Kumar |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España) |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1551-7012 |
| Popis: | A unique property of 2,4,6-trichloro-1,3,5-triazine (TCT) is its ability to undergoes a nucleophilic aromatic substitution reaction (SNAr) under temperature-controlled conditions. Using a convenient and biologically friendly protocol, mono-substituted s-triazines were treated with excess nucleophiles to obtain tri-substituted triazines in 1 + 2 mode (one nucleophile as the first substitution followed by another nucleophile for the other two positions). The nucleophiles used for this study were phenol, thiol and amine, and the best order of incorporation was phenol or thiol for the first position followed by amine for the last two positions. The work was funded by: Researchers Supporting Project at King Saud University (RSP-2020/50) (Saudi Arabia); National Research Foundation (NRF) and the University of KwaZulu-Natal (South Africa); the Spanish Ministry of Economy, Industry, and Competitiveness (MINECO) (RTI2018-093831-B-100), CIBER-BBN, and the Generalitat de Catalunya (2017 SGR 1439) (Spain). Rotimi Sheyi thanks to MINTEK for a predoctoral fellowship. |
| Databáze: | OpenAIRE |
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