Correlations between nucleotide frequencies and amino acid composition in 115 bacterial species
| Autor: | Kavitha Uthanumallian, D. Bharanidharan, Namasivayam Gautham, G. Ramya Bhargavi |
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| Rok vydání: | 2004 |
| Předmět: |
GC Rich Sequence
Statistics as Topic Biophysics Bacterial genome size Biology medicine.disease_cause Biochemistry Sensitivity and Specificity Databases Genetic medicine Nucleotide Amino Acid Sequence Amino Acids Codon Molecular Biology Gene Peptide sequence chemistry.chemical_classification Mutation Base Composition Bacteria Nucleotides Cell Biology Amino acid chemistry Genes Bacterial Nucleic acid Genome Bacterial |
| Zdroj: | Biochemical and biophysical research communications. 315(4) |
| ISSN: | 0006-291X |
| Popis: | We studied the correlations between amino acid composition and mononucleotide and dinucleotide frequencies in 115 bacterial genomes of varying G+C content. Observed amino acid frequencies were compared with those expected from the actual mononucleotide and dinucleotide frequencies. Both mononucleotide and dinucleotide frequencies correlate well with the amino acid frequency, with dinucleotide frequencies doing so better. Despite the strong correlations, some of the observed amino acid frequencies, in particular for Arg, Val, Asp, Glu, Ser, and Cys, were consistently different from predicted values in all genomes. We suggest that this variation from predicted values is a consequence of selection pressure at the level of amino acids, while the close correspondence to the predictions in residues such as Thr, Phe, Lys, and Asn arises only from mutation and selection pressure at the level of the nucleic acid sequences. |
| Databáze: | OpenAIRE |
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