A new crystal form and antimicrobial activity of (E)-1-[3-(2-hydroxybenzylideneamino)phenyl]ethanone
| Autor: | Zakaria Bouhidel, Nabila Moussa Slimane, Aouatef Cherouana |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
crystal structure
Stereochemistry Crystal structure 010402 general chemistry medicine.disease_cause 01 natural sciences Research Communications Crystal Schiff base chemistry.chemical_compound antimicrobial activity medicine General Materials Science Escherichia coli antimicrobial activity Crystallography 010405 organic chemistry Hydrogen bond new crystal form General Chemistry Condensed Matter Physics Antimicrobial 0104 chemical sciences chemistry QD901-999 Hirshfeld surfaces Monoclinic crystal system |
| Zdroj: | Acta Crystallographica Section E: Crystallographic Communications Acta Crystallographica Section E: Crystallographic Communications, Vol 74, Iss 7, Pp 884-888 (2018) |
| ISSN: | 2056-9890 |
| DOI: | 10.1107/s205698901800806x |
| Popis: | In the orthorhombic crystal form, the molecules are linked by weak C—H⋯O hydrogen bonds into supramolecular chains propagating along the b-axis direction. The title Schiff base compound, C15H13NO2, crystallizes in a new crystal form in the space group P212121, which is different from the monoclinic P21/n space group reported previously [De et al. (2009 ▸). Indian J. Chem. Sect. B, 48, 595–598]. An intramolecular O—H⋯N hydrogen bond occurs between the hydroxy and azomethine moieties. In the crystal, molecules are linked by weak C—H⋯O hydrogen bonds into supramolecular chains propagating along the b-axis direction with a C(8) graph-set motif. The contribution of these two contacts in Hirshfeld surface area are around 19 and 21%, respectively. The title compound was screened for its antibacterial activity against two gram-negative (Escherichia coli and Salmonella typhimurium) and one gram-positive (Staphyloccus aureus) bacteria. The results of this study reveal that this Schiff base shows good activity against only one bacterium, i.e. Salmonella typhimurium. |
| Databáze: | OpenAIRE |
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