Blockers of human T cell Kv1.3 potassium channels using de novo ligand design and solid-phase parallel combinatorial chemistry

Autor:	Lew A, Chamberlin Ar
Rok vydání:	1999
Předmět:	Potassium Channels Charybdotoxin medicine.drug_class Stereochemistry T cell Clinical Biochemistry Pharmaceutical Science Carboxamide Ligands complex mixtures Biochemistry Chemical synthesis chemistry.chemical_compound Phase (matter) Drug Discovery Stilbenes medicine Potassium Channel Blockers Combinatorial Chemistry Techniques Humans Channel blocker Molecular Biology Kv1.3 Potassium Channel Organic Chemistry Ligand (biochemistry) Combinatorial chemistry Potassium channel medicine.anatomical_structure chemistry Potassium Channels Voltage-Gated Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 9(23)
ISSN:	0960-894X
Popis:	Blockers of the human Kv1.3 potassium channel were designed using Biosym/MSI's ligand design program LUDI. Parallel combinatorial synthesis of the resultant substituted phenyl-stilbenes on solid phase, followed by 125I Charybdotoxin (125I ChTx) screening, yielded 12 Kv1.3 channel blockers with modest activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca9836bfab1c613639a724ed3c12470 https://pubmed.ncbi.nlm.nih.gov/10612582 Zobrazit plný text záznamu Full Text from ScienceDirect