A Cohort Study on Cancer Incidence among Women Exposed to Environmental Asbestos in Childhood with a Focus on Female Cancers, including Breast Cancer

Autor: Sofie Bünemann Dalsgaard, Else Toft Würtz, Johnni Hansen, Oluf Dimitri Røe, Øyvind Omland
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Mesothelioma
Italy/epidemiology
Occupational asbestos exposure
Lung Neoplasms
Mesothelioma/epidemiology
Breast Neoplasms/complications
Asbestos/toxicity
Health
Toxicology and Mutagenesis
uterus cancer
cancer corpus uteri
cervical cancer
mesothelioma
environmental asbestos exposure
occupational asbestos exposure
asbestos cement factory
neighborhood asbestos exposure
cancer in women
Breast Neoplasms
Lung Neoplasms/chemically induced
Cohort Studies
Occupational Exposure
Humans
Child
Cancer in women
Environmental asbestos exposure
Incidence
Occupational Exposure/adverse effects
Public Health
Environmental and Occupational Health
Asbestos
Environmental Exposure
Asbestos cement factory
Cancer corpus uteri
Neighborhood asbestos exposure
Uterus cancer
Italy
Cervical cancer
Female
Environmental Exposure/adverse effects
Zdroj: Dalsgaard, S B, Würtz, E T, Hansen, J, Røe, O D & Omland, Ø 2022, ' A Cohort Study on Cancer Incidence among Women Exposed to Environmental Asbestos in Childhood with a Focus on Female Cancers, including Breast Cancer ', International Journal of Environmental Research and Public Health, vol. 19, no. 4, 2086 . https://doi.org/10.3390/ijerph19042086
International Journal of Environmental Research and Public Health; Volume 19; Issue 4; Pages: 2086
Dalsgaard, S B, Würtz, E T, Hansen, J & Røe, O D 2022, ' A Cohort Study on Cancer Incidence among Women Exposed to Environmental Asbestos in Childhood with a Focus on Female Cancers, including Breast Cancer ', International Journal of Environmental Research and Public Health, vol. 19, no. 4, 2086 . https://doi.org/10.3390/ijerph19042086
International Journal of Environmental Research and Public Health (IJERPH)
Popis: Objectives: To examine the risk of cancer in former school children exposed to environmental asbestos in childhood with a focus on female cancers, including breast cancer. Methods: We retrieved a cohort of females (n = 6024) attending four schools located in the neighborhood of a large asbestos cement plant in Denmark. A reference cohort was frequency-matched 1:9 (n = 54,200) in sex and five-year age intervals. Using Danish registries, we linked information on historical employments, relatives’ employments, cancer, and vital status. We calculated standardized incidence rates (SIRs) for all and specific cancers, comparing these rates with the reference cohort. Hazard ratios were calculated for selected cancers adjusted for occupational and familial asbestos exposure. Results: For cancer of the corpus uteri (SIR 1.29, 95% CI 1.01–1.66) and malignant mesothelioma (SIR 7.26, 95% CI 3.26–16.15), we observed significantly increased incidences. Occupationally, asbestos exposure had a significantly increased hazard ratio for cancer in the cervix, however, a significantly lower risk of ovarian cancer. The overall cancer incidence was similar to that of the reference cohort (SIR 1.02, 95% CI 0.96–1.07). The risk of cancer of the lung was increased for those exposed to occupational asbestos, those with family members occupationally exposed to asbestos and for tobacco smokers. Conclusions: In our study, environmental asbestos exposure in childhood is associated with an increased risk of cancer of the corpus uteri and malignant mesothelioma in women.
Databáze: OpenAIRE
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