Prophylaxis with Weekly Versus Daily Fluconazole for Fungal Infections in Patients with AIDS
| Autor: | Rob Roy MacGregor, Samuel A. Bozzette, David M. Parenti, Michael P. Dubé, Diane V. Havlir, Kent A. Sepkowitz, Donald N. Forthal, J. Allen McCutchan, Carol A. Kemper, A. Clinton White, Fred R. Sattler, Stephen D. Nightingale, Mallory D. Witt, Francesca J. Torriani, Michael W. Dunne, Sarah H. Cheeseman, Princy Kumar, Michael Zelasky |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Antifungal Agents Adolescent Opportunistic infection Chemoprevention Drug Administration Schedule Double-Blind Method Acquired immunodeficiency syndrome (AIDS) Internal medicine medicine Humans Fluconazole Mycosis Aged AIDS-Related Opportunistic Infections biology business.industry Hazard ratio Middle Aged medicine.disease biology.organism_classification Survival Analysis Surgery Regimen Infectious Diseases Mycoses Chemoprophylaxis Female business Thrush medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 27:1369-1375 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/515018 |
| Popis: | We compared the efficacy of a 400-mg once-weekly dosage versus a 200-mg daily dosage of fluconazole for the prevention of deep fungal infections in a multicenter, randomized, double-blind trial of 636 human immunodeficiency virus-infected patients to determine if a less intensive fluconazole regimen could prevent these serious but relatively infrequent complications of AIDS. In the intent-to-treat analysis, a deep fungal infection developed in 17 subjects (5.5%) randomly assigned to daily fluconazole treatment and in 24 (7.7%) given weekly fluconazole during 74 weeks of follow-up (risk difference, 2.2%; 95% confidence interval [CI], -1.7% to 6.1%). Thrush occurred twice as frequently in the weekly versus daily fluconazole recipients (hazard ratio, 0.59; 95% CI, 0.40-0.89), and in a subset of patients evaluated, fluconazole resistance was infrequent. Fluconazole administered once weekly is effective in reducing deep fungal infections in patients with AIDS, but this dosage is less effective than the 200-mg-daily dosage in preventing thrush. |
| Databáze: | OpenAIRE |
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