Localized cutaneous leishmaniasis imported into Paris: a review of 39 cases
| Autor: | François Bricaire, Martin Danis, J. Carriere, Marc Thellier, Eric Caumes, Lise El Hajj |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Paris Pentamidine Isethionate Adolescent Leishmaniasis Cutaneous Dermatology Injections Intramuscular Severity of Illness Index Pharmacotherapy Age Distribution Cutaneous leishmaniasis Risk Factors Epidemiology Medicine Animals Humans Sex Distribution Adverse effect Child Pentamidine Aged Retrospective Studies Travel business.industry Incidence Retrospective cohort study Leishmaniasis Middle Aged medicine.disease Prognosis Surgery Treatment Outcome Child Preschool Female business medicine.drug |
| Zdroj: | International journal of dermatology. 43(2) |
| ISSN: | 0011-9059 |
| Popis: | Background Localized cutaneous leishmaniasis (LCL) is a common cause of dermatosis in travelers returning from the tropics. We describe the epidemiological, clinical, and biological aspects and therapeutic outcome of imported LCL. Methods A retrospective study of all cases of LCL observed from 1992 to 2000 in our tropical disease unit. Diagnosis was based on direct examination of skin smear and/or culture with identification of subsequent subspecies. Results Thirty-nine cases (25 males, 14 females; median age: 38 years) were included: 35 French travelers and four foreign immigrants; 15 cases were acquired in the Old World and 24 cases in the New World. The patients presented to our department with a median of 60 days after return. Thirteen patients had already consulted general practitioners, and the diagnosis was missed in five cases (38%). Five clusters were identified. The median number of skin lesions was two per patient. Diagnosis was established by direct microscopic examination in 36 cases (92%). Thirty-five patients were assessable for first-line treatment with antimonials (intramuscularly in 18, intralesionally in nine), intramuscular pentamidine isethionate or oral ketoconazole (four patients each). Twenty-five patients (71.4%) were cured. The remaining 10 patients were cured after one to three courses of other treatments. Overall adverse events occurred in 60% of the patients treated with antimonials and 37% of those treated with pentamidine. Conclusion Imported LCL is still unrecognized by Western physicians. Clusters may be observed in groups of travelers. The therapeutic outcome is impaired by numerous but minor side-effects. |
| Databáze: | OpenAIRE |
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