The roles of nucleolin subcellular localization in cancer
| Autor: | Xavier Gaume, Philippe Bouvet, Caroline Madeleine Berger |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cytoplasm
Nucleoplasm Cell Survival Nucleolus Cell Membrane RNA-Binding Proteins Ribosome biogenesis Cellular homeostasis General Medicine Biology Phosphoproteins Subcellular localization Biochemistry Neoplasm Proteins Cell biology Protein Transport Neoplasms Cancer cell Animals Humans Neoplasm Invasiveness Nucleolin Cell Nucleolus Cellular localization Cell Proliferation |
| Zdroj: | Biochimie. 113:78-85 |
| ISSN: | 0300-9084 |
| DOI: | 10.1016/j.biochi.2015.03.023 |
| Popis: | Nucleolin (NCL) is one of the most abundant non ribosomal protein of the nucleolus where it plays a central role in polymerase I transcription. NCL is also found outside of the nucleolus, in the nucleoplasm, cytoplasm as well as on the cell membrane. It acts in all cell compartments to control cellular homeostasis and therefore each cellular pool of NCL can play a different role in cancer development. NCL overexpression and its increased localization at the cell membrane is a common feature of several tumor cells. In cancer cells, NCL overexpression influences cell survival, proliferation and invasion through its action on different cellular pathways. In this review, we describe how the multiple functions of NCL that are associated to its multiple cellular localization can participate to the development of cancer. |
| Databáze: | OpenAIRE |
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