Halothane and isoflurane decrease alveolar epithelial fluid clearance in rats
| Autor: | Philippe Duvaldestin, Michel Meignan, Christian Jayr, Saida Rezaiguia-Delclaux, Nor-Eddine Saidi, Deng Feng Luo |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Alveolar Epithelium medicine.medical_treatment Terbutaline Blood Pressure Pulmonary Edema Permeability Rats Sprague-Dawley Body Water Internal medicine Albumins Medicine Animals Mechanical ventilation Lung Isoflurane business.industry Sodium respiratory system Adrenergic beta-Agonists Water-Electrolyte Balance Rats Pulmonary Alveoli Anesthesiology and Pain Medicine medicine.anatomical_structure Endocrinology Anesthesia Halothane Pulmonary alveolus business Clearance rate medicine.drug |
| Zdroj: | Anesthesiology. 88(3) |
| ISSN: | 0003-3022 |
| Popis: | Background Active sodium transport is the primary mechanism that drives alveolar fluid clearance. In the current study, the effects of exposure to halothane and isoflurane on alveolar fluid clearance in rats were evaluated. Methods Rats were exposed to either halothane (0.4% for 6 h or 2% for 2 h) or isoflurane (0.6% for 6 h or 2.8% for 2 h). Reversibility of halothane effects was assessed after 2 h of exposure to 2% halothane. Alveolar and lung liquid clearance were measured by intratracheal instillation of a 5% albumin solution with 1.5 microCi of 125I-albumin, during mechanical ventilation with 100% FiO2 and the halogenated agent. The effect of terbutaline (10(-4) M) added to the albumin solution was tested after 2 h of exposure to 2% halothane. The increase in protein concentration in the airspaces over 1 h was used to evaluate alveolar liquid clearance. Lung liquid clearance was calculated gravimetrically. Results Alveolar liquid clearance rates were decreased by 24%, 30% and 40% compared with controls (P < 0.05) after 2 h of exposure to halothane, 6 h of exposure to halothane, and 6 h of exposure to isoflurane, respectively. After 2 h of exposure to isoflurane, alveolar liquid clearance did not change. In the 2-h halothane exposure group, alveolar liquid clearance returned to the control value 2 h after withdrawal of halothane. Terbutaline increased alveolar liquid clearance by 50% and 89% in the control and 2-h halothane exposure groups, respectively. In all experiments, the same results were obtained for alveolar and lung liquid clearance. Conclusions Halothane and isoflurane caused a reversible decrease in alveolar epithelial fluid clearance. Two hours of exposure to halothane did not alter the stimulatory effect of terbutaline on alveolar liquid clearance. |
| Databáze: | OpenAIRE |
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