Dynamics of cytokine profile in patients with abdominal sepsis caused by pancreonecrosis

Autor: A. Kovalchuk, I. Dzyubanovsky, V. Dzhyvak, O. Dzyubanovsky, V. P. Polyovyy
Rok vydání: 2021
Předmět:
Zdroj: Journal of Education, Health and Sport, Vol 11, Iss 5, Pp 207-212 (2021)
ISSN: 2391-8306
Popis: Polyovyy V., Dzyubanovsky I., Kovalchuk A., Dzyubanovsky O., Dzhyvak V. Dynamics of cytokine profile in patients with abdominal sepsis caused by pancreonecrosis. Journal of Education, Health and Sport. 2021;11(05): 207-212. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.05.021 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.05.021 https://zenodo.org/record/5035539 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.05.2021. Revised: 21.05.2021. Accepted: 28.05.2021. DYNAMICS OF CYTOKINE PROFILE IN PATIENTS WITH ABDOMINAL SEPSIS CAUSED BY PANCREONECROSIS V. P. Polyovyy1 , I. Ya. Dzyubanovsky2 , A. A. Kovalchuk2 , O. I. Dzyubanovsky2, V. H. Dzhyvak2 1Bukovinian State Medical University 2I. Horbachevsky Ternopil National Medical University Polyovyy V. P. http://orcid.org/0000-0002-4345-9802 Dzyubanovsky I. Ya. http://orcid.org/0000-0001-8852-3938 Kovalchuk A. A. https://orcid.org/0000-0003-1394-7546 Dzyubanovsky O. I. https://orcid.org/0000-0003-4343-2797 Dzhyvak V. H. https://orcid.org/0000-0002-4885-75861 Abstract Acute pancreatitis is one of the most pressing problems of modern pancreatology, according to the authors ranks first among surgical pathologies. The aim of this study was to evaluate the dynamics of cytokine profile in patients with abdominal sepsis caused by pancreatic necrosis. Materials and methods. The study was conducted in 12 patients diagnosed with abdominal sepsis caused by pancreatic necrosis, in the period from 2017 to 2020 who were treated in medical hospitals in Chernivtsi and Ternopil. The control group consisted of 17 patients without signs of abdominal sepsis and acute surgical pathology. Both groups were representative by age, sex, comorbidities, risk factors. Determination of experimental parameters in the blood of patients was performed in the postoperative period (the results were evaluated before surgery, on the first and tenth days of the postoperative period). Research results and their discussion. In patients with abdominal sepsis, a violation of the mechanisms of cell adhesion and costimulatory-cooperative interaction of immunocompetent cells was observed in the preoperative period, as indicated by the low level of CD11a + and CD162 + expression on them. The decrease in the content of IL-6 in the blood with a slight progressive increase in the level of IL-4 corresponds to a moderate imbalance of cytokine regulation of the immune response. Key words: sepsis; cytokines; pancreatic necrosis.
Databáze: OpenAIRE
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