The effect of platelet-rich plasma in inactive form on the burn zone of stasis in rats
| Autor: | Melike Sapmaz-Metin, Ozgur Gunduz, Yeter Tarladaçalışır-Topçu, Erkan Orhan, Oktay Kaya |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Burn injury
medicine.medical_specialty Wound Healing Injections Intradermal business.industry NF-E2-Related Factor 2 Platelet-Rich Plasma Cell Count 030230 surgery Immunohistochemistry 03 medical and health sciences Disease Models Animal 0302 clinical medicine Endocrinology 030220 oncology & carcinogenesis Platelet-rich plasma Internal medicine medicine Autophagy Animals Surgery Rats Wistar business Burns |
| Zdroj: | Journal of plastic surgery and hand surgery. 53(5) |
| ISSN: | 2000-6764 |
| Popis: | The protection of the burn stasis zone tissues (BSZT) reduces the width and depth of the burn injury. In this study, it is aimed to show the effect of platelet-rich plasma (PRP) on the burn zone of stasis. Seventy-two Wistar rats were used in the study. PRP was obtained from the blood taken from eight rats. The remaining 64 rats were divided into four groups. In Group 1, only the burn procedure was performed. In Group 2, 0.3 cc of physiological saline solution, in Group 3, 0.3 cc of platelet-poor plasma and in Group 4, 0.3 cc of PRP were intradermally injected into BSZT after burn procedure. 21.5% of the tissues in Group 1, 20.8% in Group 2, 27.0% in Group 3, and 69.6% in Group 4 were found to be alive. The autophagic cell number average was calculated as 340 in Group 1, 340 in Group 2, 335 in Group 3 and 450 in Group 4, while the average number of cells stained with Nrf2 was calculated as 225 in Group 1, 245 in Group 2, 250 in Group 3 and 370 in Group 4. When the groups were compared in terms of the living tissue ratio, autophagy and number of cells stained with Nrf2, the values in Group 4 were found to be statistically significantly higher compared to Group 1, Group 2 and Group 3, while there was no difference between Groups 1, 2 and 3. This study has shown that PRP has a protective effect on BSZT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |