BUTYRATE-INDUCED DIFFERENTIATION IN LEUKEMIC MYELOID CELLS - IN-VITRO AND IN-VIVO STUDIES

Autor:	A Novogrodsky, Ester Rabizadeh, Mati Shaklai, Abraham Nudelman, Jardena Nordenberg, Adina Aviram, Ada Rephaeli, Yael Zimra
Rok vydání:	1994
Předmět:	Cancer Research Cell growth Cell Retinoic acid Sodium butyrate Butyrate Biology Prodrug In vitro chemistry.chemical_compound medicine.anatomical_structure Oncology chemistry In vivo Cancer research medicine
Zdroj:	International Journal of Oncology.
ISSN:	1791-2423 1019-6439
DOI:	10.3892/ijo.4.6.1387
Popis:	A study of the effects of three differentiating agents, butyric acid, retinoic acid and cytosine arabinoside on proliferation and differentiation of primary cultures, obtained from sixteen patients with myelo-proliferative disorder was conducted. The results showed that BA was an effective inhibitor of cell proliferation and inducer of cytodifferentiation. An acute non-lymphoblastic leukemia patient was treated with sodium butyrate. A temporary increase in differentiation-associated parameters were noted. However, the effects of SB were short-lived. The lack of clinical response led to the development of a BA prodrug pivaloyloxymethylbutyrate (AN-9). This prodrug was more potent in vitro than BA in the induction of cytodifferentiation and inhibition of cell proliferation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9ef3f28fc79218b813176f7ebd8c9b https://doi.org/10.3892/ijo.4.6.1387 Zobrazit plný text záznamu