| Autor: |
Asseyer, Susanna, Masuda, Hiroki, Mori, Masahiro, Bellmann-Strobl, Judith, Ruprecht, Klemens, Siebert, Nadja, Cooper, Graham, Chien, Claudia, Duchow, Ankelien, Schließeit, Jana, Liu, Jia, Sugimoto, Kazuo, Uzawa, Akiyuki, Ohtani, Ryohei, Paul, Friedemann, Brandt, Alexander U., Kuwabara, Satoshi, Zimmermann, Hanna G. |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Multiple Sclerosis Journal-Experimental, Translational and Clinical |
| Popis: |
Background: Clinical outcomes in neuromyelitis optica spectrum disorders (NMOSD) vary across different regions. Objective: To describe clinical profiles in Japanese and German NMOSD patients. Methods: Medical records of aquaporin-4-immunoglobulin G (AQP4-IgG) positive NMOSD patients from Japan (n = 54) and Germany (n = 38) were retrospectively analyzed. Results: The disability status was similar between both cohorts, although Japanese patients had a longer disease duration (13.3 ± 11.1 vs. 8.1 ± 6.9 years, p = 0.018) but similar relapse rates. Optic neuritis and myelitis were the most frequent attacks in both cohorts. Brain attacks occurred more frequently in Japanese patients (40.7% vs. 15.8%, p = 0.020). The time from disease onset (median [interquartile range] 2.3 [0.3-10.1] vs. 0.6 [0.2-1.9] years, p = 0.009) and the number of attacks (2.5 [1-7] vs. 2 [1-3], p = 0.047) until start of the first immunotherapy were higher in the Japanese cohort. Rituximab was the most common drug in the German cohort (52.6%) and not given in the Japanese cohort (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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