Contraction-induced muscle damage is unaffected by vitamin E supplementation
| Autor: | Louise J. Beaton, Stuart M. Phillips, Damon A Allan, Mark A. Tarnopolsky, Peter M. Tiidus |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Antioxidant Contraction (grammar) medicine.medical_treatment Physical Therapy Sports Therapy and Rehabilitation Lesion chemistry.chemical_compound Internal medicine medicine Humans Vitamin E Orthopedics and Sports Medicine Muscle Skeletal Creatine Kinase biology Muscle fatigue business.industry Biopsy Needle Nutritional Requirements Immunohistochemistry Endocrinology Torque chemistry Muscle Fatigue biology.protein Creatine kinase medicine.symptom business Muscle Contraction Muscle contraction |
| Zdroj: | Medicine & Science in Sports & Exercise. 34:798-805 |
| ISSN: | 0195-9131 |
| DOI: | 10.1097/00005768-200205000-00012 |
| Popis: | Vitamin E supplementation may confer a protective effect against eccentrically biased exercise-induced muscle damage through stabilization of the cell membrane and possibly via inhibition of free radical formation. Evidence supporting a protective role of vitamin E after contraction-induced muscle injury in humans is, however, inconsistent. The present study sought to determine the effect of vitamin E supplementation on indices of exercise-induced muscle damage and the postexercise inflammatory response after performance of repeated eccentric muscle contractions.Young healthy men performed a bout of 240 maximal isokinetic eccentric muscle contractions (0.52 rad.s-1) after being supplemented for 30 d with either vitamin E (N = 9; 1200 IU.d-1) or placebo (N = 7; safflower oil).Measurements of torque (isometric and concentric) decreased (P0.05) below preexercise values immediately post- and at 48 h post-exercise. Biopsies taken 24 h postexercise showed a significant increase in the amount of extensive Z-band disruption (P0.01); however, neither the torque deficit nor the extent of Z-band disruption were affected by vitamin E. Exercise resulted in increased macrophage cell infiltration (P = 0.05) into muscle, which was also unaffected by vitamin E. Serum CK also increased as a result of the exercise (P0.05) with no effect of vitamin E.We conclude that vitamin E supplementation (30 d at 1200 IU.d-1), which resulted in a 2.8-fold higher serum vitamin E concentration (P0.01), had no affect on indices of contraction-induced muscle damage nor inflammation (macrophage infiltration) as a result of eccentrically biased muscle contractions. |
| Databáze: | OpenAIRE |
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