| Autor: |
Elise Romain, Fabrice Chemla, Martin Oestreich, Franck Ferreira, Carolin Fopp, Alejandro Perez-Luna, Olivier Jackowski |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Angewandte Chemie (International ed. in English). 53(42) |
| ISSN: |
1521-3773 |
| Popis: |
The silylzincation of terminal ynamides is achieved through a radical-chain process involving (Me3Si)3SiH and R2Zn. A potentially competing polar mechanism is excluded on the basis of diagnostic control experiments. The unique feature of this addition across the C≡C bond is its trans selectivity. One-pot electrophilic substitution of the C(sp2)-Zn bond by Cu(I)-mediated C-C bond formation and subsequent manipulation of the C(sp2)-Si bond provides a modular access to Z-α,β-disubstituted enamides. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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