Relation of ETS transcription factor family member ERG, androgen receptor and topoisomerase 2β expression to TMPRSS2-ERG fusion status in prostate cancer
| Autor: | M. Bienova, Vladimír Študent, Zdenek Kolar, Milan Král, Jan Bouchal, R. Kucerova, T. Jamaspishvili, Alena Burdova |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Cancer Research Oncogene Proteins Fusion genetic structures medicine.drug_class Biology TMPRSS2 Malignant transformation Fusion gene Prostate cancer Transcriptional Regulator ERG medicine Humans Poly-ADP-Ribose Binding Proteins Gene Rearrangement ETS transcription factor family Prostatic Neoplasms Gene rearrangement medicine.disease Androgen Immunohistochemistry eye diseases DNA-Binding Proteins Androgen receptor DNA Topoisomerases Type II Oncology Receptors Androgen Trans-Activators Cancer research sense organs Gene Fusion |
| Zdroj: | Neoplasma. 61:9-16 |
| ISSN: | 1338-4317 |
| Popis: | Fusion of TMPRSS2 with ERG in prostate cells is determined by double-strand DNA breaks induced by androgen signaling and transcription stress. The enzyme topoisomerase 2β (TOP2B) mediating DNA processing, plays an important role in DNA cleavage. The aim of this study was to analyse expression of AR, TOP2B and ERG in relation to TMPRSS2-ERG gene rearrangement and relevant clinicopathological characteristics in prostate cancer (CaP). Immunohistochemical staining and FISH were used for investigation. ERG expression in prostate cell lesions positively correlated with levels of TMPRSS2-ERG fusion gene (p |
| Databáze: | OpenAIRE |
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