Phospholipase C activity in microorganisms associated with reproductive tract infection
| Autor: | James A. McGregor, David W. Lawellin, Jim Todd, Amalia Franco-Buff |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Phosphorylcholine
Phospholipase medicine.disease_cause Salpingitis Substrate Specificity Microbiology Bacteria Anaerobic Pregnancy medicine Humans Gardnerella vaginalis biology Phospholipase C Streptococcus Obstetrics and Gynecology Bacterial Infections Genitalia Female biology.organism_classification Bacteria Aerobic Chorioamnionitis Type C Phospholipases Puerperal Infection Female Bacteroides fragilis Endometritis Bacteria Lecithinase |
| Zdroj: | American Journal of Obstetrics and Gynecology. 164:682-686 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/s0002-9378(11)80046-3 |
| Popis: | Phospholipase C (lecithinase or phosphatidylcholine Phosphorylase) catalyzes the hydrolysis of lecithin into phosphorylcholine and 1,2-diglyceride. Bacterial production of phospholipase C may damage reproductive tract tissues by both direct and indirect mechanisms. Use of the synthetic substrate p-nitrophenylphosphorylcholine polspholipase C activity was determined in 204 isolates representative of those found in female genital tract. Multiple aerobic (28%) and anaerobic (28%) reproductive tract microorganisms showed phospholipase C activity. Phospholipase C-producing isolates included strains of Bacteroides fragilis, B. bivius, B. thetaiotaomicron, Gardnerella vaginalis , and group B streptococcus. Phospholipase C activity was heterogenous; not all isolates that belong to a particular species showed activity. Phospholipase C production may be a possible virulence factor produced by a number of microflora commonly implicated in various reproductive tract infections or conditions, as well as in some instances of preterm birth. |
| Databáze: | OpenAIRE |
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