Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of tumors implanted in rat livers by inducing platinum-DNA adducts to form and massive apoptosis
| Autor: | Fumio Nishikaku, Toshihiro Noguchi, Akemi Baba, Yasuyuki Tsutsumishita, Mitsuharu Hanada, Nobuyoshi Chiba, Takashi Yamaoka |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Cancer Research Programmed cell death Pathology medicine.medical_specialty Lipiodol Organoplatinum Compounds Hepatocellular carcinoma Miriplatin Platinum-DNA adducts chemistry.chemical_element Apoptosis Antineoplastic Agents Pharmacology Toxicology DNA Adducts Hepatic Artery Liver Neoplasms Experimental medicine Animals Infusions Intra-Arterial Pharmacology (medical) Chemoembolization Therapeutic Cisplatin Drug Carriers business.industry Lymphography Iodized Oil medicine.disease Rats Oncology chemistry Delayed-Action Preparations Original Article Drug Screening Assays Antitumor Liver cancer Drug carrier Platinum business Neoplasm Transplantation medicine.drug |
| Zdroj: | Cancer Chemotherapy and Pharmacology |
| ISSN: | 1432-0843 0344-5704 |
| DOI: | 10.1007/s00280-008-0895-3 |
| Popis: | Background Miriplatin (formerly SM-11355), a novel lipophilic platinum complex developed to treat hepatocellular carcinoma, is administered into the hepatic artery using an oily lymphographic agent (Lipiodol Ultra-Fluide®) as a carrier. We clarified the usefulness of miriplatin as an agent for transarterial chemoembolization. Methods Platinum compounds released from miriplatin into serum, medium and Earle’s balanced salt solution were examined. Then, miriplatin and cisplatin were administered to rats bearing hepatoma AH109A tumors in livers. Platinum concentrations in tissues and DNA were assessed. Results Miriplatin showed a more sustained release than cisplatin. Dichloro[(1R, 2R)-1, 2-cyclohexane diamine-N, N′]platinum, the most abundant platinum compound released from miriplatin, was as effective as cisplatin in inhibiting the growth of cells. Miriplatin was selectively disposed of in tumors, maintained in tumors longer than cisplatin and caused apparent tumor regression inducing platinum-DNA adducts to form and massive apoptosis. Conclusion Miriplatin appears to be a suitable chemotherapeutic agent for transarterial chemoembolization. |
| Databáze: | OpenAIRE |
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