The Combination of the Tumor Markers Suggests the Histological Diagnosis of Lung Cancer

Autor: Peishan Cong, Zhijun Liu, Mingjun Liu, Teng Yu, Guirong Sun, Linjie Liu, Yuan Yao, Lijun Zhang, Jinlong Teng
Rok vydání: 2017
Předmět:
Adult
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Article Subject
lcsh:Medicine
Tumor M2-PK
General Biochemistry
Genetics and Molecular Biology
Diagnosis
Differential
03 medical and health sciences
0302 clinical medicine
Antigen
Antigens
Neoplasm
Carcinoma
Non-Small-Cell Lung
Histological diagnosis
Internal medicine
Biomarkers
Tumor
medicine
Carcinoma
Humans
Lung cancer
neoplasms
Serpins
Aged
Keratin-19
General Immunology and Microbiology
business.industry
lcsh:R
Clinical performance
General Medicine
Middle Aged
medicine.disease
Small Cell Lung Carcinoma
Peptide Fragments
Recombinant Proteins
Carcinoembryonic Antigen
respiratory tract diseases
Squamous carcinoma
030104 developmental biology
CA-125 Antigen
030220 oncology & carcinogenesis
Adenocarcinoma
Female
Carrier Proteins
business
Research Article
Zdroj: BioMed Research International, Vol 2017 (2017)
BioMed Research International
ISSN: 2314-6141
2314-6133
DOI: 10.1155/2017/2013989
Popis: Tumor markers are beneficial for the diagnosis and therapy monitoring of lung cancer. However, the value of tumor markers in lung cancer histological diagnosis is unknown. In this study, we analyzed the serum levels of six tumor markers (CEA, CYFRA21-1, SCC, NSE, ProGRP, and CA125) in 2097 suspected patients with lung cancer and determined whether the combination of the tumor markers was useful for histological diagnosis of lung cancer. We found that CYFRA21-1 was the most sensitive marker in NSCLC. ProGRP showed a better clinical performance than that of NSE in discriminating between SCLC and NSCLC. The serum level of CYFRA21-1 or SCC was significantly higher in squamous carcinoma (p<0.05), and the levels of ProGRP and NSE were significantly higher in SCLC (p<0.05). According to the criteria established, SCLC and NSCLC were discriminated with sensitivity of 87.12 and 62.63% and specificity of 64.61 and 99.5%, respectively. The sensitivity and specificity in the differentiation of adenocarcinoma and squamous carcinoma were 68.1 and 81.63% and 70.73 and 65.93%, with NPV of 46.03 and 68.97% and PPV of 85.82 and 79.47%, respectively. Our results suggested the combination of six tumor markers could discriminate the histological types of lung cancer.
Databáze: OpenAIRE
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