Clinical Characteristics, Choroidal Neovascularization, and Predictors of Visual Outcomes in Acquired Vitelliform Lesions
Autor: | Christine A. Curcio, K. Bailey Freund, Rosa Dolz-Marco, Lawrence A. Yannuzzi, Quan V Hoang, Chandrakumar Balaratnasingam, Maiko Inoue, Nicolas A. Yannuzzi, Elona Dhrami-Gavazi |
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Rok vydání: | 2016 |
Předmět: |
Male
0301 basic medicine Fovea Centralis medicine.medical_specialty Time Factors Visual acuity genetic structures Fundus Oculi Visual Acuity 03 medical and health sciences 0302 clinical medicine Ophthalmology parasitic diseases Humans Medicine Fluorescein Angiography Aged Retrospective Studies medicine.diagnostic_test business.industry Dystrophy Mean age Retrospective cohort study Foveal atrophy Macular degeneration Prognosis Fluorescein angiography medicine.disease Choroidal Neovascularization eye diseases Vitelliform Macular Dystrophy Surgery 030104 developmental biology Choroidal neovascularization Disease Progression 030221 ophthalmology & optometry Female sense organs medicine.symptom business Tomography Optical Coherence Follow-Up Studies |
Zdroj: | American Journal of Ophthalmology. 172:28-38 |
ISSN: | 0002-9394 |
Popis: | To quantify the temporal properties of the acquired vitelliform lesion (AVL) life cycle, define the clinical characteristics of choroidal neovascularization (NV) in this setting, and determine the predictors of long-term visual outcomes.Retrospective cohort study.Clinical and imaging data from 199 eyes of 124 consecutive patients with AVLs associated with age-related macular degeneration (AMD) and adult-onset foveomacular vitelliform dystrophy (AOFVD) were analyzed. Volumetric calculations of vitelliform material were determined using spectral-domain optical coherence tomography and the temporal properties of the AVL life cycle were quantified. The clinical characteristics of NV were assessed, as were the predictors of final best-corrected visual acuity (BCVA) and change in BCVA.Mean age was 79.2 ± 12.1 years. AVLs grew and collapsed at approximately the same rate (P = .275). Fifteen eyes (7.5%) developed NV, of which all were type 1. In 13 of these eyes, NV occurred during the collapse phase of the AVL life cycle, after the peak AVL volume was reached. The risk of NV (P = .006) and the decline in BCVA (P = .001) were both significantly greater among eyes with AMD. Foveal atrophy was the characteristic most significantly associated with final BCVA and change in BCVA from baseline (both P.0005). The development of NV was not predictive of long-term visual outcomes (all P = .216).Complications associated with AVLs typically occur during the collapse phase of the AVL life cycle. Visual outcomes and risk of NV are related to the underlying disease associated with AVLs. |
Databáze: | OpenAIRE |
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