How Does COVID-19 Affect the Neurobiology of Suicide?
| Autor: | Conejero, I., Nobile, B., Olié, E., Courtet, Ph, Courtet, Ph. |
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| Přispěvatelé: | Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Lapeyronie [Montpellier] (CHU), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Michel-Avella, Amandine |
| Rok vydání: | 2021 |
| Předmět: |
MESH: Pandemics
Psychotropic treatments Coronavirus disease 2019 (COVID-19) MESH: Coronavirus Infections [SDV]Life Sciences [q-bio] Vulnerability Context (language use) Affect (psychology) Suicide prevention Mood Disorders (E Baca-Garcia Section Editor) 03 medical and health sciences 0302 clinical medicine medicine MESH: COVID-19 Humans MESH: SARS-CoV-2 Social isolation Pandemics Inflammation MESH: Humans SARS-CoV-2 Social distance HPA axis COVID-19 030227 psychiatry [SDV] Life Sciences [q-bio] Psychiatry and Mental health Suicide MESH: Suicide Suicidal vulnerability Disconnection medicine.symptom Psychology Coronavirus Infections Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current Psychiatry Reports Current Psychiatry Reports, Current Medicine Group, 2021, 23 (4), pp.16. ⟨10.1007/s11920-021-01227-x⟩ |
| ISSN: | 1535-1645 1523-3812 |
| Popis: | International audience; Purpose of review: The aim of this review was to analyze COVID-19 effect on the biological features of suicidal vulnerability and its interaction with suicide-related biological pathways. We carried out a narrative review of international publications on the interactions of COVID-19 with the biological bases of suicide.Recent findings: We hypothesize that SARS-CoV-2 interacts with multiple biological processes that underlie suicidal behavior, such as the renin-angiotensin system, nicotinic receptors, and central and systemic inflammation. Social distancing measures may also worsen subjective or objective social disconnection, thus increasing the risk of suicide. Interestingly, the drugs used to prevent suicide could be promising options to counteract brain damage caused by this coronavirus. SARS-CoV-2 interacts with multiple biological pathways involved in suicide and opens a new window for understanding the suicidal process. The development of suicide prevention treatments in the context of a pandemic may benefit from knowledge on these interactions. |
| Databáze: | OpenAIRE |
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