Constituents of Tinospora sinensis and their nitric oxide inhibitory activities
| Autor: | Anh, Bui Thi Mai, Trang, Do Thi, Lan, Hoang Thi Tuyet, Van Kiem, Phan, Tai, Bui Huu, Dung, Nguyen Viet, Nam, Ninh Khach Thanh, Nguyen The Cuong, Nhiem, Nguyen Xuan, Thi, Nguyen |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Asian Natural Products Research. :1-7 |
| ISSN: | 1477-2213 1028-6020 |
| DOI: | 10.1080/10286020.2022.2113975 |
| Popis: | One new phenylpropanoid glycoside, tinosinen A (1) and 13 known compounds, tinosinen (2), citrusin B (3), picraquassioside C (4), erythro-guaiacylglycerol-β-O-4′-coniferyl alcohol (5), erythro-guaiacylglycerol-8-O-4′-(sinapyl alcohol) ether (6), erythro-syringylglycerol-8-O-4′-(sinapyl alcohol) ether (7), seco-isolariciresinol 9-O-D-β-glucopyranoside (8), tinosposide A (9), pinoresinol-4′-O-β-D-glucopyranoside (10), syringaresinol-4′-O-β-D-glucopyranoside (11), pinoresinol (12), syringaresinol (13), and lirioresino-β-dimethyl ether (14) were isolated from the stems of Tinospora sinensis (Lour.) Merr. Their structures were established by detailed spectroscopic studies and comparisons with those reported in the literature. Compound 13 showed significant inhibitory NO production (IC50 value of 38.53 ± 1.90 μM) in RAW264.7 macrophages, LPS-stimulated. Compounds 3–7, 11, 12, and 14 inhibited NO production with IC50 values ranging from 38.53 to 99.07 μM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|