Interleukin-2 can induce proliferation of leukemic B-cells in prolymphocytic leukemia
| Autor: | Peter Reizenstein, Rodica Lenkei, Panayotides P, Anna Porwit |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Interleukin 2
Male medicine.drug_class Biology Immunofluorescence Monoclonal antibody Cell surface receptor medicine Humans Prolymphocytic leukemia Receptor Cells Cultured Aged B-Lymphocytes medicine.diagnostic_test Antibodies Monoclonal Hematology General Medicine DNA medicine.disease Virology Molecular biology In vitro Recombinant Proteins Leukemia Lymphoid Phenotype Cell culture Immunologic Techniques Interleukin-2 Cell Division medicine.drug |
| Zdroj: | European journal of haematology. 38(3) |
| ISSN: | 0902-4441 |
| Popis: | In a case of prolymphocytic leukemia (PLL), receptors for interleukin-2 (IL-2R) were demonstrated by immunofluorescence with a monoclonal antibody against IL-2R. Highly purified leukemic B-cells, cultured in vitro with recombinant IL-2 (r-IL-2), responded to IL-2 with a marked increase of DNA-synthesis. Both spontaneous and r-IL-2-induced proliferation of leukemic cells were totally abrogated by the anti-IL-2R monoclonal antibody. |
| Databáze: | OpenAIRE |
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