Preventive effect ofPueraria mirificaon testosterone-induced prostatic hyperplasia in Sprague Dawley rats
| Autor: | S. S. Masrudin, Jamaludin Mohamad |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Urology Prostatic Hyperplasia Genistein Pharmacology Plant Roots Rats Sprague-Dawley chemistry.chemical_compound Endocrinology Prostate Internal medicine medicine Animals Testosterone biology Plant Extracts Body Weight Daidzein food and beverages Organ Size General Medicine Hyperplasia biology.organism_classification medicine.disease Isoflavones Rats Pueraria medicine.anatomical_structure chemistry Dihydrotestosterone Finasteride Phytotherapy medicine.drug Pueraria mirifica |
| Zdroj: | Andrologia. 47:1153-1159 |
| ISSN: | 0303-4569 |
| DOI: | 10.1111/and.12396 |
| Popis: | Summary Pueraria mirifica (PM) extract contains phytoestrogen daidzein and genistein. In this study, we investigated the protective effect of PM extract, daidzein and genistein on a testosterone-induced prostatic hyperplasia in rats. Testosterone was administered at 3 mg kg � 1 to rats followed by the PM extract, daidzein and genistein for a period of 30 days with finasteride as positive control. The testosterone level was increased, indicating inhibition of 5a-reductase converting testosterone to dihydrotestosterone. This was confirmed by prostate-specific antigen level that significantly decreased when treated with PM extract, daidzein and genistein. The PM extract, daidzein and genistein reduced the increase in the prostate/body weight ratio in testosterone-induced rats. This gives indication that PM extract, daidzein and genistein possessed protective activity for the treatment of benign prostatic hyperplasia. The analysis of histoarchitechture of the prostate has also shown that there was a significant improvement in prostatic cells of the testosterone-induced rats when treated with PM extract, daidzein and genistein. |
| Databáze: | OpenAIRE |
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